In its attempt to lower inflation, the Federal Reserve has raised its policy interest rate target to the highest level in 17 years. Much has occurred in economies and markets over this long stretch of time, including the Great Recession and the pandemic-induced, worldwide downturn. Four U.S. presidents have occupied the White House, and three chairpersons have led the Fed. Overall, it has been a period characterized by historically low interest rates. How has this low-rate regime impacted the fortunes of workers and investors? A review of trends in key indicators can provide perspective for economic activity and investing ahead.