The pandemic’s impact has been felt around the world in so many ways. Of course, most devastating have been the extreme loss of life and the lingering health consequences for many virus survivors. At the outset, daily life changed abruptly from measures taken to contain virus spread. As recovery has progressed and virus variants have emerged, new life patterns have developed. However, dependencies once taken for granted have been derailed and the consequences persist. They are seen in supply chain disruptions, labor supply/demand imbalances, and the impact of government policies. A review of some important dependencies can provide perspective for investing yet ahead.